Drug interactions
Erythromycin + Oliceridine
Severity: Major
Erythromycin and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise oliceridine concentrations, increasing the risk of respiratory depression and sedation. Stopping the inhibitor later can lower opioid levels and reduce analgesia.
What this interaction means in plain words
Erythromycin and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Oliceridine belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition by erythromycin reduces oliceridine metabolism.
What to do
Use less frequent or lower oliceridine doses and monitor closely for respiratory depression and sedation. Re-titrate if erythromycin is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Erythromycin with Oliceridine?
MediHelp rates the interaction as major. Erythromycin and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may raise oliceridine concentrations, increasing the risk of respiratory depression and sedation. Stopping the inhibitor later can lower opioid levels and reduce analgesia.
How serious is the interaction between Erythromycin and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use less frequent or lower oliceridine doses and monitor closely for respiratory depression and sedation. Re-titrate if erythromycin is discontinued.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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