Drug interactions
Erythromycin + Pemigatinib
Severity: Moderate
Erythromycin and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase pemigatinib concentrations through CYP3A4 inhibition, raising the risk of hyperphosphatemia-related and other toxicities, including eye and nail effects.
What this interaction means in plain words
Erythromycin and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Pemigatinib belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of pemigatinib.
What to do
Choose a non-CYP3A4-inhibiting antibiotic where possible. If combined, reduce the pemigatinib dose per labeling and monitor for adverse effects and serum phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin and Pemigatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Erythromycin with Pemigatinib?
MediHelp rates the interaction as moderate. Erythromycin and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase pemigatinib concentrations through CYP3A4 inhibition, raising the risk of hyperphosphatemia-related and other toxicities, including eye and nail effects.
How serious is the interaction between Erythromycin and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-CYP3A4-inhibiting antibiotic where possible. If combined, reduce the pemigatinib dose per labeling and monitor for adverse effects and serum phosphate.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
