Drug interactions
Erythromycin + Pexidartinib
Severity: Major
Erythromycin and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise pexidartinib exposure through CYP3A4 inhibition, and both agents can cause liver injury. Pexidartinib carries a boxed warning for serious hepatotoxicity, so added risk is clinically important.
What this interaction means in plain words
Erythromycin and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4 metabolism of pexidartinib, and both drugs have hepatotoxic potential.
What to do
Avoid the combination when possible and use a safer antibiotic. If unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Erythromycin with Pexidartinib?
MediHelp rates the interaction as major. Erythromycin and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may raise pexidartinib exposure through CYP3A4 inhibition, and both agents can cause liver injury. Pexidartinib carries a boxed warning for serious hepatotoxicity, so added risk is clinically important.
How serious is the interaction between Erythromycin and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use a safer antibiotic. If unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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