Drug interactions
Erythromycin + Pivmecillinam
Severity: Minor
Erythromycin and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A theoretical antagonism exists between erythromycin and the bactericidal beta-lactam mecillinam, released from pivmecillinam. Evidence of clinical consequence is lacking.
What this interaction means in plain words
Erythromycin and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic macrolide and a bactericidal cell wall inhibitor.
What to do
No routine change is needed; monitor clinical response if both agents are required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Erythromycin with Pivmecillinam?
MediHelp rates the interaction as minor. Erythromycin and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A theoretical antagonism exists between erythromycin and the bactericidal beta-lactam mecillinam, released from pivmecillinam. Evidence of clinical consequence is lacking.
How serious is the interaction between Erythromycin and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor clinical response if both agents are required.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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