Drug interactions
Erythromycin + Sparsentan
Severity: Moderate
Erythromycin and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase sparsentan exposure by inhibiting CYP3A4. Higher levels could worsen hypotension, hyperkalemia, edema or renal effects, and hepatotoxicity risk.
What this interaction means in plain words
Erythromycin and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Sparsentan belongs to Genitourinary.
Why it happens
Moderate CYP3A4 inhibition by erythromycin reduces sparsentan metabolism.
What to do
No empirical dose change is required. Monitor blood pressure, serum potassium, fluid status, liver tests and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Erythromycin with Sparsentan?
MediHelp rates the interaction as moderate. Erythromycin and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase sparsentan exposure by inhibiting CYP3A4. Higher levels could worsen hypotension, hyperkalemia, edema or renal effects, and hepatotoxicity risk.
How serious is the interaction between Erythromycin and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor blood pressure, serum potassium, fluid status, liver tests and renal function.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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