Drug interactions
Erythromycin + Tamsulosin
Severity: Moderate
Erythromycin and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise tamsulosin levels via CYP3A4 inhibition. This may increase hypotension, dizziness and syncope, especially in older patients.
What this interaction means in plain words
Erythromycin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Tamsulosin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by erythromycin reduces tamsulosin clearance.
What to do
Counsel patients about orthostatic dizziness and monitor blood pressure. Consider an alternative antibiotic for longer courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Erythromycin with Tamsulosin?
MediHelp rates the interaction as moderate. Erythromycin and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may raise tamsulosin levels via CYP3A4 inhibition. This may increase hypotension, dizziness and syncope, especially in older patients.
How serious is the interaction between Erythromycin and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about orthostatic dizziness and monitor blood pressure. Consider an alternative antibiotic for longer courses.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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