Drug interactions
Erythromycin base + Gentamicin
Severity: Minor
Erythromycin base and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A P-glycoprotein effect of erythromycin on gentamicin is theoretical, and no clear rise in gentamicin exposure has been established in practice. Both drugs can be ototoxic, and erythromycin itself may cause reversible hearing loss, which could add to aminoglycoside ototoxicity.
What this interaction means in plain words
Erythromycin base and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition by erythromycin; possible additive ototoxicity.
What to do
No dose change is needed routinely. Monitor hearing and renal function during prolonged or high-dose therapy, and use gentamicin levels as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Erythromycin base with Gentamicin?
MediHelp rates the interaction as minor. Erythromycin base and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A P-glycoprotein effect of erythromycin on gentamicin is theoretical, and no clear rise in gentamicin exposure has been established in practice. Both drugs can be ototoxic, and erythromycin itself may cause reversible hearing loss, which could add to aminoglycoside ototoxicity.
How serious is the interaction between Erythromycin base and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor hearing and renal function during prolonged or high-dose therapy, and use gentamicin levels as usual.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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