Drug interactions
Erythromycin base + Haloperidol
Severity: Major
Erythromycin base and Haloperidol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and inhibits CYP3A4, which contributes to haloperidol clearance. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Erythromycin base and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with erythromycin inhibition of CYP3A4 raising haloperidol concentrations.
What to do
Prefer a non-macrolide antibiotic such as one without QT effects. If used together, monitor the ECG and electrolytes and watch for haloperidol toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Erythromycin base with Haloperidol?
MediHelp rates the interaction as major. Erythromycin base and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin prolongs the QT interval and inhibits CYP3A4, which contributes to haloperidol clearance. The combination raises the risk of torsades de pointes.
How serious is the interaction between Erythromycin base and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-macrolide antibiotic such as one without QT effects. If used together, monitor the ECG and electrolytes and watch for haloperidol toxicity.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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