Drug interactions
Erythromycin ethylsuccinate + Flibanserin
Severity: Contraindicated
Erythromycin ethylsuccinate and Flibanserin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin ethylsuccinate delivers erythromycin, a moderate CYP3A4 inhibitor, which can increase flibanserin exposure. Severe hypotension and syncope become more likely.
What this interaction means in plain words
Erythromycin ethylsuccinate and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 reduces flibanserin clearance.
What to do
Avoid; select an antibiotic that does not inhibit CYP3A4 or withhold flibanserin during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Flibanserin?
MediHelp rates the interaction as contraindicated. Erythromycin ethylsuccinate and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin ethylsuccinate delivers erythromycin, a moderate CYP3A4 inhibitor, which can increase flibanserin exposure. Severe hypotension and syncope become more likely.
How serious is the interaction between Erythromycin ethylsuccinate and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; select an antibiotic that does not inhibit CYP3A4 or withhold flibanserin during treatment.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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