Drug interactions
Erythromycin ethylsuccinate + Fluvoxamine
Severity: Moderate
Erythromycin ethylsuccinate and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval and can cause torsades de pointes. Fluvoxamine may add to this effect and inhibits CYP3A4, which may raise erythromycin levels.
What this interaction means in plain words
Erythromycin ethylsuccinate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by both drugs.
What to do
Monitor ECG in patients with other QT risk factors. Correct potassium and magnesium disturbances and consider an alternative antibiotic where risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Fluvoxamine?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval and can cause torsades de pointes. Fluvoxamine may add to this effect and inhibits CYP3A4, which may raise erythromycin levels.
How serious is the interaction between Erythromycin ethylsuccinate and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with other QT risk factors. Correct potassium and magnesium disturbances and consider an alternative antibiotic where risk is high.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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