Drug interactions
Erythromycin ethylsuccinate + Rimegepant
Severity: Moderate
Erythromycin ethylsuccinate and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 moderately and P-glycoprotein, which can increase rimegepant exposure. This may increase adverse effects.
What this interaction means in plain words
Erythromycin ethylsuccinate and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces rimegepant clearance.
What to do
Avoid a second rimegepant dose within 48 hours of the first while erythromycin is taken. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin ethylsuccinate and Rimegepant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rimegepant
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Rimegepant?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 moderately and P-glycoprotein, which can increase rimegepant exposure. This may increase adverse effects.
How serious is the interaction between Erythromycin ethylsuccinate and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours of the first while erythromycin is taken. Monitor tolerability.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
