Drug interactions
Erythromycin ethylsuccinate + Saxagliptin
Severity: Moderate
Erythromycin ethylsuccinate and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and raises saxagliptin and its active metabolite exposure modestly. The increase is generally not large enough to need dose changes in most patients.
What this interaction means in plain words
Erythromycin ethylsuccinate and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of saxagliptin by erythromycin.
What to do
No routine dose adjustment is required; monitor for hypoglycemia and adverse effects, especially with renal impairment or other interacting drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Erythromycin ethylsuccinate with Saxagliptin?
MediHelp rates the interaction as moderate. Erythromycin ethylsuccinate and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and raises saxagliptin and its active metabolite exposure modestly. The increase is generally not large enough to need dose changes in most patients.
How serious is the interaction between Erythromycin ethylsuccinate and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required; monitor for hypoglycemia and adverse effects, especially with renal impairment or other interacting drugs.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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