Drug interactions
Erythromycin stearate + Etonogestrel
Severity: Minor
Erythromycin stearate and Etonogestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may raise etonogestrel concentrations modestly. Higher progestin exposure could increase hormonal adverse effects, but contraceptive efficacy is not expected to fall.
What this interaction means in plain words
Erythromycin stearate and Etonogestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of etonogestrel, which may reduce its clearance.
What to do
No change to the implant or ring is generally needed; tell the patient to report increased progestogenic effects such as headache, mood change or bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Frequently asked questions
Can I take Erythromycin stearate with Etonogestrel?
MediHelp rates the interaction as minor. Erythromycin stearate and Etonogestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may raise etonogestrel concentrations modestly. Higher progestin exposure could increase hormonal adverse effects, but contraceptive efficacy is not expected to fall.
How serious is the interaction between Erythromycin stearate and Etonogestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change to the implant or ring is generally needed; tell the patient to report increased progestogenic effects such as headache, mood change or bleeding changes.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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