Drug interactions
Escitalopram + Eslicarbazepine
Severity: Moderate
Escitalopram and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19, which may increase escitalopram concentrations. This could raise the risk of dose-related adverse effects, including QT prolongation.
What this interaction means in plain words
Escitalopram and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine inhibits CYP2C19, reducing escitalopram metabolism; it also has some inducing effects on CYP3A4.
What to do
Monitor for escitalopram adverse effects such as nausea, sedation or palpitations and reduce the dose if needed. Consider an ECG if the dose is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Escitalopram with Eslicarbazepine?
MediHelp rates the interaction as moderate. Escitalopram and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19, which may increase escitalopram concentrations. This could raise the risk of dose-related adverse effects, including QT prolongation.
How serious is the interaction between Escitalopram and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects such as nausea, sedation or palpitations and reduce the dose if needed. Consider an ECG if the dose is high.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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