Drug interactions
Escitalopram + Etravirine
Severity: Moderate
Escitalopram and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C19 and induces CYP3A4, so it may change escitalopram exposure, with inhibition likely to predominate for this CYP2C19 substrate. The result is typically modest, with possible increases in escitalopram adverse effects.
What this interaction means in plain words
Escitalopram and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibits CYP2C19 and induces CYP3A4, both involved in escitalopram metabolism.
What to do
Monitor for escitalopram adverse effects such as nausea, agitation and QT-related symptoms, as well as for loss of efficacy. Adjust the escitalopram dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Escitalopram with Etravirine?
MediHelp rates the interaction as moderate. Escitalopram and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C19 and induces CYP3A4, so it may change escitalopram exposure, with inhibition likely to predominate for this CYP2C19 substrate. The result is typically modest, with possible increases in escitalopram adverse effects.
How serious is the interaction between Escitalopram and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects such as nausea, agitation and QT-related symptoms, as well as for loss of efficacy. Adjust the escitalopram dose according to clinical response.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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