Drug interactions
Escitalopram + Furosemide
Severity: Moderate
Escitalopram and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diuretics and SSRIs can each cause hyponatremia, and together the risk is increased. Elderly patients are most vulnerable, and low sodium may present as confusion, nausea or falls.
What this interaction means in plain words
Escitalopram and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced sodium loss combined with SSRI-associated SIADH produces additive hyponatremia.
What to do
Measure serum sodium at baseline and shortly after starting or changing doses. Reassess the antidepressant if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Furosemide?
MediHelp rates the interaction as moderate. Escitalopram and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diuretics and SSRIs can each cause hyponatremia, and together the risk is increased. Elderly patients are most vulnerable, and low sodium may present as confusion, nausea or falls.
How serious is the interaction between Escitalopram and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum sodium at baseline and shortly after starting or changing doses. Reassess the antidepressant if sodium falls significantly.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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