Drug interactions
Escitalopram + Gilteritinib
Severity: Major
Escitalopram and Gilteritinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Gilteritinib activity may also be affected by drugs acting on serotonin 5-HT2B or sigma receptors.
What this interaction means in plain words
Escitalopram and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Escitalopram belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive QTc prolongation, with possible pharmacodynamic receptor-level interference with gilteritinib.
What to do
Consider an alternative antidepressant during gilteritinib therapy; if combined, monitor ECG and electrolytes and respond to QTc prolongation per gilteritinib guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Escitalopram with Gilteritinib?
MediHelp rates the interaction as major. Escitalopram and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Gilteritinib activity may also be affected by drugs acting on serotonin 5-HT2B or sigma receptors.
How serious is the interaction between Escitalopram and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidepressant during gilteritinib therapy; if combined, monitor ECG and electrolytes and respond to QTc prolongation per gilteritinib guidance.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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