Drug interactions
Escitalopram + Lasmiditan
Severity: Moderate
Escitalopram and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan is a 5-HT1F agonist that commonly causes dizziness and sedation. Escitalopram adds serotonergic activity and some CNS effects. The combination may increase sedation, and serotonin syndrome is a theoretical concern.
What this interaction means in plain words
Escitalopram and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects and potential additive serotonergic activity; lasmiditan has no vasoconstrictive or 5-HT1B/1D activity, so serotonin syndrome risk is theoretical.
What to do
Counsel patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for sedation and for signs of serotonin toxicity such as agitation, tremor, clonus and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Escitalopram with Lasmiditan?
MediHelp rates the interaction as moderate. Escitalopram and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan is a 5-HT1F agonist that commonly causes dizziness and sedation. Escitalopram adds serotonergic activity and some CNS effects. The combination may increase sedation, and serotonin syndrome is a theoretical concern.
How serious is the interaction between Escitalopram and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive for at least 8 hours after a lasmiditan dose. Monitor for sedation and for signs of serotonin toxicity such as agitation, tremor, clonus and hyperthermia.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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