Drug interactions
Escitalopram + Metoprolol
Severity: Minor
Escitalopram and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram is a weak CYP2D6 inhibitor and may modestly raise metoprolol exposure. This can occasionally cause more bradycardia or hypotension, though the effect is usually small.
What this interaction means in plain words
Escitalopram and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6-mediated metoprolol metabolism by escitalopram.
What to do
Monitor heart rate and blood pressure when starting or changing escitalopram, and reduce the metoprolol dose if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Escitalopram and Metoprolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Metoprolol?
MediHelp rates the interaction as minor. Escitalopram and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Escitalopram is a weak CYP2D6 inhibitor and may modestly raise metoprolol exposure. This can occasionally cause more bradycardia or hypotension, though the effect is usually small.
How serious is the interaction between Escitalopram and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or changing escitalopram, and reduce the metoprolol dose if symptomatic bradycardia occurs.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
