Drug interactions
Escitalopram + Omeprazole
Severity: Moderate
Escitalopram and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19, which is a main route of escitalopram metabolism, raising escitalopram concentrations. This may increase QT prolongation and serotonergic adverse effects.
What this interaction means in plain words
Escitalopram and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19-mediated metabolism of escitalopram.
What to do
Limit escitalopram dose when used with omeprazole, per labeling (maximum 20 mg daily is already the ceiling; consider lower doses in older adults), and monitor for adverse effects and QT prolongation in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Omeprazole?
MediHelp rates the interaction as moderate. Escitalopram and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole inhibits CYP2C19, which is a main route of escitalopram metabolism, raising escitalopram concentrations. This may increase QT prolongation and serotonergic adverse effects.
How serious is the interaction between Escitalopram and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit escitalopram dose when used with omeprazole, per labeling (maximum 20 mg daily is already the ceiling; consider lower doses in older adults), and monitor for adverse effects and QT prolongation in at-risk patients.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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