Drug interactions
Escitalopram + Osimertinib
Severity: Moderate
Escitalopram and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval and escitalopram has a dose-related QT effect. Together they may increase the risk of torsades de pointes.
What this interaction means in plain words
Escitalopram and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Perform periodic ECG and electrolyte monitoring. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Escitalopram with Osimertinib?
MediHelp rates the interaction as moderate. Escitalopram and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval and escitalopram has a dose-related QT effect. Together they may increase the risk of torsades de pointes.
How serious is the interaction between Escitalopram and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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