Drug interactions
Escitalopram + Piroxicam
Severity: Moderate
Escitalopram and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram combined with an NSAID increases the risk of upper gastrointestinal bleeding beyond either drug alone. Older patients and those with prior GI bleeding are at greatest risk.
What this interaction means in plain words
Escitalopram and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
SSRI depletion of platelet serotonin and NSAID platelet and mucosal effects are additive.
What to do
Avoid if possible or add a proton pump inhibitor and limit NSAID duration. Counsel on signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Escitalopram with Piroxicam?
MediHelp rates the interaction as moderate. Escitalopram and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Escitalopram combined with an NSAID increases the risk of upper gastrointestinal bleeding beyond either drug alone. Older patients and those with prior GI bleeding are at greatest risk.
How serious is the interaction between Escitalopram and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or add a proton pump inhibitor and limit NSAID duration. Counsel on signs of GI bleeding.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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