Drug interactions
Escitalopram + Selinexor
Severity: Moderate
Escitalopram and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, fatigue, and other neurological adverse effects. Escitalopram can also cause dizziness and sedation, so additive central nervous system effects are possible. This is a predicted pharmacodynamic overlap rather than a well-characterized interaction.
What this interaction means in plain words
Escitalopram and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Overlapping CNS adverse effects; no specific pharmacokinetic interaction is established.
What to do
Monitor for dizziness, confusion, and falls, particularly during the first treatment cycles. Reduce or hold selinexor per labeling if neurological toxicity develops, and review the need for other CNS-active drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Escitalopram and Selinexor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Escitalopram with Selinexor?
MediHelp rates the interaction as moderate. Escitalopram and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, fatigue, and other neurological adverse effects. Escitalopram can also cause dizziness and sedation, so additive central nervous system effects are possible. This is a predicted pharmacodynamic overlap rather than a well-characterized interaction.
How serious is the interaction between Escitalopram and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion, and falls, particularly during the first treatment cycles. Reduce or hold selinexor per labeling if neurological toxicity develops, and review the need for other CNS-active drugs.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
