Drug interactions
Escitalopram + Tipranavir
Severity: Moderate
Escitalopram and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly affects CYP enzymes and may alter escitalopram exposure. Net inhibition of CYP3A4 and possibly 2C19 could raise escitalopram levels and increase the risk of QT prolongation and serotonergic adverse effects, while tipranavir's inducing effects may offset this.
What this interaction means in plain words
Escitalopram and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir modulates CYP3A4 and CYP2C19, which contribute to escitalopram metabolism.
What to do
Monitor for escitalopram adverse effects, including QT prolongation, and consider an ECG in patients with additional risk factors. Keep the escitalopram dose at the lowest effective level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Escitalopram with Tipranavir?
MediHelp rates the interaction as moderate. Escitalopram and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, strongly affects CYP enzymes and may alter escitalopram exposure. Net inhibition of CYP3A4 and possibly 2C19 could raise escitalopram levels and increase the risk of QT prolongation and serotonergic adverse effects, while tipranavir's inducing effects may offset this.
How serious is the interaction between Escitalopram and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects, including QT prolongation, and consider an ECG in patients with additional risk factors. Keep the escitalopram dose at the lowest effective level.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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