Drug interactions
Escitalopram + Vorinostat
Severity: Moderate
Escitalopram and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and escitalopram also prolongs the QT interval. The combination may add to the risk of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Escitalopram and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Escitalopram belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes, correcting potassium and magnesium disturbances. Repeat the ECG if symptoms or other QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Escitalopram with Vorinostat?
MediHelp rates the interaction as moderate. Escitalopram and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and escitalopram also prolongs the QT interval. The combination may add to the risk of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Escitalopram and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correcting potassium and magnesium disturbances. Repeat the ECG if symptoms or other QT-prolonging drugs are added.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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