Drug interactions
Esketamine + Flibanserin
Severity: Moderate
Esketamine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin causes somnolence, dizziness and hypotension or syncope, particularly with other CNS depressants. Combined use with esketamine may worsen sedation and impair alertness.
What this interaction means in plain words
Esketamine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Avoid taking flibanserin on esketamine treatment days when possible, and monitor for sedation and low blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Esketamine with Flibanserin?
MediHelp rates the interaction as moderate. Esketamine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin causes somnolence, dizziness and hypotension or syncope, particularly with other CNS depressants. Combined use with esketamine may worsen sedation and impair alertness.
How serious is the interaction between Esketamine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking flibanserin on esketamine treatment days when possible, and monitor for sedation and low blood pressure.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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