Drug interactions
Esketamine + Haloperidol
Severity: Moderate
Esketamine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol can cause sedation and orthostatic effects, which may be added to esketamine's sedation and dissociation. Impaired alertness and coordination are more likely with combined use.
What this interaction means in plain words
Esketamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor sedation during the post-dose observation period and advise against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Esketamine with Haloperidol?
MediHelp rates the interaction as moderate. Esketamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol can cause sedation and orthostatic effects, which may be added to esketamine's sedation and dissociation. Impaired alertness and coordination are more likely with combined use.
How serious is the interaction between Esketamine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during the post-dose observation period and advise against driving until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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