Drug interactions
Esketamine + Iloperidone
Severity: Moderate
Esketamine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating atypical antipsychotic that may add to the drowsiness and dizziness caused by esketamine. It can also cause orthostatic hypotension and QT prolongation, which are relevant in a patient monitored for blood pressure changes after esketamine.
What this interaction means in plain words
Esketamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects from antipsychotic receptor blockade combined with NMDA antagonism.
What to do
Monitor sedation and blood pressure during and after esketamine dosing, and check an ECG if there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esketamine and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esketamine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Esketamine with Iloperidone?
MediHelp rates the interaction as moderate. Esketamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating atypical antipsychotic that may add to the drowsiness and dizziness caused by esketamine. It can also cause orthostatic hypotension and QT prolongation, which are relevant in a patient monitored for blood pressure changes after esketamine.
How serious is the interaction between Esketamine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine dosing, and check an ECG if there are other QT risk factors.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
