Drug interactions
Esketamine + Lasmiditan
Severity: Moderate
Esketamine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes dizziness and sedation, which may add to esketamine's sedative and dissociative effects. Combined use has not been formally studied.
What this interaction means in plain words
Esketamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant and neuropsychiatric effects.
What to do
Monitor for sedation and cognitive impairment after dosing and advise patients not to drive for at least 8 hours after lasmiditan and until the day after esketamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Esketamine with Lasmiditan?
MediHelp rates the interaction as moderate. Esketamine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes dizziness and sedation, which may add to esketamine's sedative and dissociative effects. Combined use has not been formally studied.
How serious is the interaction between Esketamine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive impairment after dosing and advise patients not to drive for at least 8 hours after lasmiditan and until the day after esketamine.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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