Drug interactions
Esketamine + Pomalidomide
Severity: Minor
Esketamine and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide can cause drowsiness, fatigue and dizziness, which may add modestly to esketamine's sedative effects. The interaction is mostly additive adverse effects rather than a strong pharmacological interaction.
What this interaction means in plain words
Esketamine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Pomalidomide belongs to Miscellaneous.
Why it happens
Additive CNS adverse effects; no established pharmacokinetic interaction.
What to do
Counsel patients about additive drowsiness and observe them during the post-dose period. No dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Esketamine with Pomalidomide?
MediHelp rates the interaction as minor. Esketamine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide can cause drowsiness, fatigue and dizziness, which may add modestly to esketamine's sedative effects. The interaction is mostly additive adverse effects rather than a strong pharmacological interaction.
How serious is the interaction between Esketamine and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and observe them during the post-dose period. No dose adjustment is usually needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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