Drug interactions
Fluvoxamine + Pomalidomide
Severity: Major
Fluvoxamine and Pomalidomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is metabolized in part by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that can raise pomalidomide exposure. This may increase myelosuppression and other adverse effects.
What this interaction means in plain words
Fluvoxamine and Pomalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Pomalidomide belongs to Miscellaneous.
Why it happens
Strong CYP1A2 inhibition by fluvoxamine reduces pomalidomide metabolism.
What to do
Avoid if possible; if coadministered, reduce the pomalidomide dose as labeled and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
- Ciprofloxacin + Pomalidomide Moderate
Frequently asked questions
Can I take Fluvoxamine with Pomalidomide?
MediHelp rates the interaction as major. Fluvoxamine and Pomalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pomalidomide is metabolized in part by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that can raise pomalidomide exposure. This may increase myelosuppression and other adverse effects.
How serious is the interaction between Fluvoxamine and Pomalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if coadministered, reduce the pomalidomide dose as labeled and monitor blood counts.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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