Drug interactions
Carbamazepine + Pomalidomide
Severity: Moderate
Carbamazepine and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce pomalidomide exposure and compromise its efficacy in myeloma. The effect is predicted from the metabolic pathways involved and is not well quantified clinically.
What this interaction means in plain words
Carbamazepine and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Pomalidomide belongs to Miscellaneous.
Why it happens
Carbamazepine induces CYP1A2 and CYP3A4 and may affect P-glycoprotein, potentially increasing pomalidomide clearance.
What to do
Monitor myeloma response and consider a non-inducing anticonvulsant. Pomalidomide dose adjustment is not specified, so decisions should be individualized.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Ciprofloxacin + Pomalidomide Moderate
Frequently asked questions
Can I take Carbamazepine with Pomalidomide?
MediHelp rates the interaction as moderate. Carbamazepine and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce pomalidomide exposure and compromise its efficacy in myeloma. The effect is predicted from the metabolic pathways involved and is not well quantified clinically.
How serious is the interaction between Carbamazepine and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor myeloma response and consider a non-inducing anticonvulsant. Pomalidomide dose adjustment is not specified, so decisions should be individualized.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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