Drug interactions
Apalutamide + Pomalidomide
Severity: Moderate
Apalutamide and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, so apalutamide may modestly lower exposure. The clinical significance is likely limited.
What this interaction means in plain words
Apalutamide and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Pomalidomide belongs to Miscellaneous.
Why it happens
Apalutamide induces CYP3A4, which partly metabolizes pomalidomide.
What to do
Monitor disease response and consider dose adjustment per clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
- Ciprofloxacin + Pomalidomide Moderate
Frequently asked questions
Can I take Apalutamide with Pomalidomide?
MediHelp rates the interaction as moderate. Apalutamide and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, so apalutamide may modestly lower exposure. The clinical significance is likely limited.
How serious is the interaction between Apalutamide and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and consider dose adjustment per clinical response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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