Drug interactions
Esketamine + Sulpiride
Severity: Moderate
Esketamine and Sulpiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulpiride can cause sedation, and combining it with esketamine may increase drowsiness and impair psychomotor performance. The effect is typically modest.
What this interaction means in plain words
Esketamine and Sulpiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Sulpiride belongs to Central Nervous System.
Why it happens
Additive CNS depression from D2/D3 antagonism and NMDA antagonism.
What to do
Monitor sedation after esketamine dosing and advise against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Sulpiride
- Escitalopram + Sulpiride Major
- Empagliflozin + Sulpiride Moderate
- Esomeprazole + Sulpiride Moderate
- Metformin + Sulpiride Moderate
- Propranolol + Sulpiride Moderate
Frequently asked questions
Can I take Esketamine with Sulpiride?
MediHelp rates the interaction as moderate. Esketamine and Sulpiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulpiride can cause sedation, and combining it with esketamine may increase drowsiness and impair psychomotor performance. The effect is typically modest.
How serious is the interaction between Esketamine and Sulpiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after esketamine dosing and advise against driving until the next day.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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