Drug interactions
Propranolol + Sulpiride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive blood pressure lowering and bradycardia may occur, increasing risk of dizziness, orthostatic hypotension, and syncope, particularly at initiation or with dose titration.
Mechanism of action
Pharmacodynamic: combined antihypertensive effects and negative chronotropy; no meaningful pharmacokinetic interaction expected (sulpiride is renally eliminated).
Clinical management
Monitor blood pressure and heart rate at baseline and after dose changes; use slow titration and consider dose adjustments; counsel patients on orthostatic precautions.
Drug reference
References
- Sulpiride Summary of Product Characteristics (UK) – Orthostatic hypotension and cardiovascular cautions — MHRA SmPC
- Propranolol Prescribing Information – Warnings (bradycardia and hypotension) — FDA Label
- Drug Interactions: Antipsychotics with antihypertensives/beta‑blockers — Lexicomp
Frequently asked questions
Can I take Propranolol with Sulpiride?
The interaction is rated: Moderate. Additive blood pressure lowering and bradycardia may occur, increasing risk of dizziness, orthostatic hypotension, and syncope, particularly at initiation or with dose titration.
How serious is the interaction between Propranolol and Sulpiride?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between Propranolol and Sulpiride managed?
Monitor blood pressure and heart rate at baseline and after dose changes; use slow titration and consider dose adjustments; counsel patients on orthostatic precautions.
Why do Propranolol and Sulpiride interact?
Pharmacodynamic: combined antihypertensive effects and negative chronotropy; no meaningful pharmacokinetic interaction expected (sulpiride is renally eliminated).
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