Drug interactions
Esketamine + Temazepam
Severity: Moderate
Esketamine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine and the benzodiazepine temazepam both depress the central nervous system. Combined use can intensify sedation, impair psychomotor function and may worsen respiratory depression.
What this interaction means in plain words
Esketamine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esketamine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through NMDA receptor antagonism and GABA-A potentiation.
What to do
Monitor sedation and respiratory status after esketamine administration. Avoid taking temazepam before esketamine sessions where possible and reduce the dose if over-sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Esketamine with Temazepam?
MediHelp rates the interaction as moderate. Esketamine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine and the benzodiazepine temazepam both depress the central nervous system. Combined use can intensify sedation, impair psychomotor function and may worsen respiratory depression.
How serious is the interaction between Esketamine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after esketamine administration. Avoid taking temazepam before esketamine sessions where possible and reduce the dose if over-sedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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