Drug interactions
Esketamine intranasal + Flibanserin
Severity: Moderate
Esketamine intranasal and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, dizziness and dissociation, and flibanserin can lower blood pressure and cause syncope. Combined use may increase impairment and the risk of falls.
What this interaction means in plain words
Esketamine intranasal and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant and sedative effects.
What to do
Monitor for sedation and hypotension, and advise against driving or hazardous tasks after dosing. Consider spacing flibanserin (taken at bedtime) away from esketamine sessions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Flibanserin?
MediHelp rates the interaction as moderate. Esketamine intranasal and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, dizziness and dissociation, and flibanserin can lower blood pressure and cause syncope. Combined use may increase impairment and the risk of falls.
How serious is the interaction between Esketamine intranasal and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and hypotension, and advise against driving or hazardous tasks after dosing. Consider spacing flibanserin (taken at bedtime) away from esketamine sessions.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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