Drug interactions
Esketamine intranasal + Haloperidol
Severity: Moderate
Esketamine intranasal and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and blood pressure elevation, and CNS depressants such as haloperidol may add to sedation. Dopamine blockade may also reduce some psychotomimetic effects, but the combination requires observation after dosing.
What this interaction means in plain words
Esketamine intranasal and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor sedation and blood pressure during and after each esketamine session, as required by labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Haloperidol?
MediHelp rates the interaction as moderate. Esketamine intranasal and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and blood pressure elevation, and CNS depressants such as haloperidol may add to sedation. Dopamine blockade may also reduce some psychotomimetic effects, but the combination requires observation after dosing.
How serious is the interaction between Esketamine intranasal and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after each esketamine session, as required by labeling.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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