Drug interactions
Esketamine intranasal + Lurasidone
Severity: Moderate
Esketamine intranasal and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation and dizziness, and esketamine also causes dissociation and blood pressure elevation. Combined use may increase CNS depression and impair alertness after dosing.
What this interaction means in plain words
Esketamine intranasal and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and sedative effects.
What to do
Monitor sedation and blood pressure during the post-dose observation period and advise against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Lurasidone?
MediHelp rates the interaction as moderate. Esketamine intranasal and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation and dizziness, and esketamine also causes dissociation and blood pressure elevation. Combined use may increase CNS depression and impair alertness after dosing.
How serious is the interaction between Esketamine intranasal and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during the post-dose observation period and advise against driving until the next day.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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