Drug interactions
Esketamine intranasal + Pentazocine
Severity: Moderate
Esketamine intranasal and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and pentazocine adds opioid-related sedation and respiratory depression. Together they may increase the degree of drowsiness and impair alertness after the esketamine session.
What this interaction means in plain words
Esketamine intranasal and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and respiratory status during and after esketamine administration in patients taking pentazocine. Esketamine must be given in a supervised setting with observation until the patient is stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Esketamine intranasal with Pentazocine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and pentazocine adds opioid-related sedation and respiratory depression. Together they may increase the degree of drowsiness and impair alertness after the esketamine session.
How serious is the interaction between Esketamine intranasal and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status during and after esketamine administration in patients taking pentazocine. Esketamine must be given in a supervised setting with observation until the patient is stable.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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