Drug interactions
Eslicarbazepine + Fentanyl
Severity: Moderate
Eslicarbazepine and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce fentanyl exposure, leading to reduced analgesia or withdrawal in dependent patients. Fentanyl levels can increase when the inducer is stopped.
What this interaction means in plain words
Eslicarbazepine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4-mediated fentanyl metabolism by eslicarbazepine.
What to do
Monitor pain control and withdrawal symptoms and adjust the fentanyl dose accordingly. Reduce the fentanyl dose and monitor for sedation if eslicarbazepine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Fentanyl?
MediHelp rates the interaction as moderate. Eslicarbazepine and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce fentanyl exposure, leading to reduced analgesia or withdrawal in dependent patients. Fentanyl levels can increase when the inducer is stopped.
How serious is the interaction between Eslicarbazepine and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal symptoms and adjust the fentanyl dose accordingly. Reduce the fentanyl dose and monitor for sedation if eslicarbazepine is discontinued.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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