Drug interactions
Eslicarbazepine + Fosamprenavir
Severity: Moderate
Eslicarbazepine and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, which is cleared by CYP3A4. Eslicarbazepine may lower amprenavir levels and risk loss of virologic control.
What this interaction means in plain words
Eslicarbazepine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by eslicarbazepine increases amprenavir metabolism.
What to do
Monitor HIV viral load and consider therapeutic drug monitoring. Prefer a non-inducing antiseizure drug if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Fosamprenavir?
MediHelp rates the interaction as moderate. Eslicarbazepine and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, which is cleared by CYP3A4. Eslicarbazepine may lower amprenavir levels and risk loss of virologic control.
How serious is the interaction between Eslicarbazepine and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider therapeutic drug monitoring. Prefer a non-inducing antiseizure drug if control is lost.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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