Drug interactions
Eslicarbazepine + Glecaprevir / pibrentasvir
Severity: Major
Eslicarbazepine and Glecaprevir / pibrentasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a CYP3A4 and P-gp inducer and may lower glecaprevir and pibrentasvir concentrations. Reduced exposure could lead to loss of antiviral activity and failure to achieve sustained virologic response.
What this interaction means in plain words
Eslicarbazepine and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases the clearance of both antiviral components.
What to do
Avoid the combination where possible and choose an alternative antiepileptic with less enzyme induction. If unavoidable, monitor HCV response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as major. Eslicarbazepine and Glecaprevir / pibrentasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine is a CYP3A4 and P-gp inducer and may lower glecaprevir and pibrentasvir concentrations. Reduced exposure could lead to loss of antiviral activity and failure to achieve sustained virologic response.
How serious is the interaction between Eslicarbazepine and Glecaprevir / pibrentasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antiepileptic with less enzyme induction. If unavoidable, monitor HCV response closely.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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