Drug interactions
Eslicarbazepine + Hydrocortisone
Severity: Moderate
Eslicarbazepine and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may speed up hydrocortisone metabolism, lowering its exposure. This could reduce glucocorticoid effect, which matters mainly in patients on replacement therapy for adrenal insufficiency.
What this interaction means in plain words
Eslicarbazepine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases hepatic clearance of hydrocortisone.
What to do
Monitor for signs of inadequate steroid effect and adjust the hydrocortisone dose if needed, particularly in adrenal insufficiency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Hydrocortisone?
MediHelp rates the interaction as moderate. Eslicarbazepine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may speed up hydrocortisone metabolism, lowering its exposure. This could reduce glucocorticoid effect, which matters mainly in patients on replacement therapy for adrenal insufficiency.
How serious is the interaction between Eslicarbazepine and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of inadequate steroid effect and adjust the hydrocortisone dose if needed, particularly in adrenal insufficiency.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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