Drug interactions
Eslicarbazepine + Irinotecan liposomal
Severity: Moderate
Eslicarbazepine and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated to SN-38 and also inactivated by CYP3A4, and inducers have been shown to reduce exposure to irinotecan and SN-38 with conventional formulations. Eslicarbazepine may therefore reduce efficacy of liposomal irinotecan.
What this interaction means in plain words
Eslicarbazepine and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by eslicarbazepine increases oxidative metabolism of irinotecan to inactive metabolites.
What to do
Prefer a non-inducing antiseizure drug; if combined, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Eslicarbazepine and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is activated to SN-38 and also inactivated by CYP3A4, and inducers have been shown to reduce exposure to irinotecan and SN-38 with conventional formulations. Eslicarbazepine may therefore reduce efficacy of liposomal irinotecan.
How serious is the interaction between Eslicarbazepine and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug; if combined, monitor tumor response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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