Drug interactions
Eslicarbazepine + Levonorgestrel intrauterine
Severity: Minor
Eslicarbazepine and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine lowers systemic levonorgestrel from oral and implant products. With an intrauterine system the effect is mainly local, so contraceptive efficacy is largely preserved, though systemic levels may fall slightly.
What this interaction means in plain words
Eslicarbazepine and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by eslicarbazepine increases levonorgestrel metabolism, with limited relevance to the locally acting intrauterine system.
What to do
The intrauterine system can generally be continued as a reliable contraceptive option. Advise on additional contraception only if used for systemic purposes such as endometrial protection with estrogen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Eslicarbazepine and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine lowers systemic levonorgestrel from oral and implant products. With an intrauterine system the effect is mainly local, so contraceptive efficacy is largely preserved, though systemic levels may fall slightly.
How serious is the interaction between Eslicarbazepine and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The intrauterine system can generally be continued as a reliable contraceptive option. Advise on additional contraception only if used for systemic purposes such as endometrial protection with estrogen.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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