Drug interactions
Eslicarbazepine + Parecoxib
Severity: Minor
Eslicarbazepine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Eslicarbazepine may slightly lower valdecoxib concentrations, with limited clinical effect expected.
What this interaction means in plain words
Eslicarbazepine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak enzyme induction by eslicarbazepine may increase hepatic metabolism of valdecoxib.
What to do
No routine adjustment is needed. Assess analgesic response and adjust the dose if pain control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Parecoxib?
MediHelp rates the interaction as minor. Eslicarbazepine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Eslicarbazepine may slightly lower valdecoxib concentrations, with limited clinical effect expected.
How serious is the interaction between Eslicarbazepine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Assess analgesic response and adjust the dose if pain control is inadequate.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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