Drug interactions
Eslicarbazepine + Pimozide
Severity: Moderate
Eslicarbazepine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and may modestly lower pimozide levels, potentially reducing efficacy. Pimozide may also lower seizure threshold, opposing the anticonvulsant.
What this interaction means in plain words
Eslicarbazepine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by eslicarbazepine; antipsychotic lowering of seizure threshold.
What to do
Monitor pimozide response and seizure control, and adjust dose if efficacy changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Pimozide?
MediHelp rates the interaction as moderate. Eslicarbazepine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak CYP3A4 inducer and may modestly lower pimozide levels, potentially reducing efficacy. Pimozide may also lower seizure threshold, opposing the anticonvulsant.
How serious is the interaction between Eslicarbazepine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pimozide response and seizure control, and adjust dose if efficacy changes.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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