Drug interactions
Eslicarbazepine + Progesterone micronized
Severity: Moderate
Eslicarbazepine and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a CYP3A4 inducer and may lower progesterone levels, lessening endometrial protection or luteal support. The legacy hint about CYP2C19 is not a clinically relevant pathway for progesterone.
What this interaction means in plain words
Eslicarbazepine and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by eslicarbazepine increases progesterone metabolism.
What to do
Monitor for reduced progestogenic effect such as breakthrough bleeding, and consider a dose increase or alternative therapy. Avoid relying on it for contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Progesterone micronized?
MediHelp rates the interaction as moderate. Eslicarbazepine and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a CYP3A4 inducer and may lower progesterone levels, lessening endometrial protection or luteal support. The legacy hint about CYP2C19 is not a clinically relevant pathway for progesterone.
How serious is the interaction between Eslicarbazepine and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestogenic effect such as breakthrough bleeding, and consider a dose increase or alternative therapy. Avoid relying on it for contraception.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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