Drug interactions
Eslicarbazepine + Romidepsin
Severity: Moderate
Eslicarbazepine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4, so enzyme induction may lower its exposure. This could reduce antitumor efficacy, though the effect with a weak inducer like eslicarbazepine is likely modest.
What this interaction means in plain words
Eslicarbazepine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Eslicarbazepine induces CYP3A4, increasing romidepsin clearance.
What to do
Prefer a non-inducing antiseizure agent when possible. If coadministered, monitor for reduced treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eslicarbazepine and Romidepsin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Romidepsin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is metabolized mainly by CYP3A4, so enzyme induction may lower its exposure. This could reduce antitumor efficacy, though the effect with a weak inducer like eslicarbazepine is likely modest.
How serious is the interaction between Eslicarbazepine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure agent when possible. If coadministered, monitor for reduced treatment response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
